Bioinformatics and research in life sciences and technologies: a review of the work conducted at the Laboratory of Genetic Engineering and Cellular and Molecular Biology

Abstract

Bioinformatics has become a central component of life sciences and technologies, enabling the integration of computational, mathematical, and statistical methods for the analysis of large volumes of data. In the present work, a review of the historical evolution of bioinformatics is presented through the contributions and developments carried out at the Laboratory of Genetic Engineering and Cellular and Molecular Biology – Insect Virosis Area (LIGBCM-AVI) of the Quilmes National University. The main conceptual and technological changes that occurred from the pregonomic era, characterized by the study of individual genes through Sanger sequencing, to the postgenomic era, driven by high-throughput sequencing technologies and the integrated analysis of genomes, transcriptomes, proteomes, and other biological datasets, are described. Finally, the impact of bioinformatics on LIGBCM basic and applied research, its integration into academic training, and future challenges associated with the development of multi-omics strategies, artificial intelligence, and systems biology are discussed.